BIX01294, UNC0638, UNC0642, and A‐366 have been screened extensively in both cellular and in vivo studies to gain insight into the biological functions of G9a and GLP.[4, 5, 6] However, UNC0638 has been found to exhibit strong antiproliferative effects against cancer cells, whereas other complementary G9a/GLP chemical probes such as A‐366 have failed to reproduce these phenotypes.[7] These observations suggest additional unknown targets beyond G9a and GLP. This evidence concerns the gene EHMT1 and cancer.