Both proteins can also methylate a variety of other non‐histone substrates such as the tumour suppressor p53, sirtuin 1 (SIRT1), myogenic differentiation 1 (MyoD), chromodomain Y‐like protein (CDYL1) and widely‐interspaced zinc finger‐containing protein (WIZ).[3] Dysregulation of G9a and/or GLP has been implicated in many human diseases such as cancer, inflammatory diseases, and neurodegenerative conditions. The gene discussed is SIRT1; the disease is cancer.