2021; A. Ren et al. 2021; Weng et al. 2021). In sporadic CCM, CCM gene mutation frequently co‐occur with PIK3CA gain‐of‐function mutation (Weng et al. 2021). The incidence of PIK3CA gain‐of‐function mutations in sporadic CCM is higher than that of CCM gene mutations (McDonald et al. 2014). Creating mouse models with this mutation is challenging, likely due to embryonic lethality (Castel, Rauen, and McCormick 2020), which results from angiogenesis abnormalities and severe vascular malformations during early embryonic development (Schonning et al. 2021; Hare et al. 2015; Luks et al. 2015). Here, PIK3CA is linked to cerebral cavernous malformation.