2019). In CCM1+/−Msh2−/−, CCM2+/−Trp53−/−, PDCD10+/−Trp53−/−, and PDCD10+/−Msh2−/−mice, simvastatin reduced chronic bleeding of CCM lesions but did not improve survival or reduce lesion burden (Shenkar et al. 2019, 2017). Here, CCM2 is linked to cerebral cavernous malformation.