To identify the lysine lactylation sites in tau associated with AD, we analyzed lysine lactylation as a PTM of tau using a published, publicly available quantitative proteomics (MS) data set by mass spectrometry that analyzed tau PTMs in postmortem control and AD human brain samples from parietal cortex (Brodmann area 39 [BA39]: angular gyrus).18 Here, MAPT is linked to Alzheimer disease.