Instead, we discovered new serum biomarkers in IC/BPS, including representatives of cytokines (IFNα, IL1RA, BAFF), chemokines (CCL11, CCL27), growth factors (HBEGF, HGF), proteins involved in tissue repair (MMP9, CHI3L1) and the adhesion molecule ICAM1. The gene discussed is MMP9; the disease is Bartsocas-Papas syndrome 1.