HBEGF and Bartsocas-Papas syndrome 1: Instead, we discovered new serum biomarkers in IC/BPS, including representatives of cytokines (IFNα, IL1RA, BAFF), chemokines (CCL11, CCL27), growth factors (HBEGF, HGF), proteins involved in tissue repair (MMP9, CHI3L1) and the adhesion molecule ICAM1.