PRNP and neurodegenerative disease: In neurodegenerative diseases, Sti1 as a central protein of such proteostasis networks, may abnormally stabilize misfolded proteins, such as Amyloid‐β [83], α‐synuclein [84], TDP‐43 [88], and PrPC [20], and thus either decrease or increase their toxicity [20, 83, 84] by mechanisms that warrant further investigation.