Notably, upregulation of Sti1 promotes proliferation in multiple cancer cell lines where other members of the proteostasis system are similarly upregulated [39, 68, 69, 70, 71, 72, 73], suggesting that the toxicity associated with exogenous overexpression may stem from increased Sti1 levels independent of an upregulated proteostasis network. The gene discussed is STIP1; the disease is cancer.