Cancer cells reprogram normal fibroblasts into CAFs, initiating tumor‐favorable signaling, including pro‐EMT signaling through secretion of TGF‐β [28], as well as remodeling of extracellular matrix to make it more favorable for tumor escape and invasion and creating a barrier to immune cell infiltration and penetration of anticancer drugs [29]. The gene discussed is TGFB1; the disease is cancer.