TARDBP and amyotrophic lateral sclerosis: In Amyotrophic Lateral Sclerosis (ALS) and Frontal Temporal Lobe Dementia (FTLD) patients, inclusion bodies are often observed in affected regions in the central nervous system (CNS), including the hippocampus, neocortex, and spinal cord, with deposition of TDP-43 aggregates [2].