NAMPT and neoplasm: F. nucleatum inhibits butyric acid to promote tumor progression via the AMPK signaling pathway.[43] Previous studies have demonstrated that intestinal AMPK is a possible upstream mediator of intestinal NAMPT‐mediated NAD+ biosynthesis and may play a central role in maintaining intestinal homeostasis, including microbial composition.[44] Therefore, F. nucleatum might affect NAMPT‐mediated NAD+ biosynthesis by regulating AMPK.