NAD+ regulates glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation‐driven energy metabolism through redox reactions.[39] Recent studies have shown that F. nucleatum can increase intracellular glycolysis in colon cancer cells to promote tumorigenesis.[40] In addition, F. nucleatum is positively correlated with the levels of several plasma lipid metabolites[41] and plays a key role in lipid homeostasis in the apoptosis induced by NAMPT inhibitors,[42] suggesting that F. nucleatum may be involved in glycolipid metabolism. Here, NAMPT is linked to malignant colon neoplasm.