NAMPT is also associated with intestinal inflammation in patients with IBD[14] and is correlated with the response to anti‐TNF therapy in these patients.[16, 17] In this study, we verified the changes in the expression of key enzymes of the NAD+ synthesis pathway via RT‐PCR, which revealed that F. nucleatum infection upregulated the expression of the NAMPT, NRK1, NRK2, and NADS genes. The gene discussed is TNF; the disease is inflammatory bowel disease.