Considering the aerobic nature of LR, a reactive oxygen species (ROS)‐cleavable linker was employed to connect LR with CDs and CpG‐encapsulated mulberry leaf lipid (MLL) nanoparticles (LNPs), which enabled the prolonged retention of CD/CpG@LNPs in the colorectal tumors.[37] After oral administration, LR‐S‐CD/CpG@LNPs preferentially accumulated in the colorectal regions rich in ROS, causing the linkers to be broken and facilitating the accumulation of CD/CpG@LNPs into the colorectal tumors. Here, KMT2A is linked to colorectal neoplasm.