The impaired activity of TRPC5 was linked to a reduction in calprotectin levels, likely because calprotectin interacts with Toll‐like receptor 4,[33] which in turn stimulates diacylglycerol production.[34] Whether other mechanisms contribute to TRPC5 hyperactivation after AD injection remains to be established and requires further study. This evidence concerns the gene TRPC5 and Alzheimer disease.