CXCL13 and colorectal cancer: As a B cell chemokine, CXCL13 has also been demonstrated in other cancer types to effectively induce the formation of TLS.[39] In a mouse ovarian cancer model, recombinant CXCL13 protein induced TLS formation and improved survival.[40] Similarly, in a colorectal cancer liver metastasis model, intra‐tumoral injection of CCL19/CXCL13 promoted TLS formation.[41] Future studies could focus on inducing TLS formation by enhancing CXCL13 expression as a potential therapeutic strategy for MIBC.