A recent study highlights that UDP‐driven signaling pathways, mediated by cytidine deaminase (CDA) and P2Y6 receptor, are critical in tumor‐associated macrophage (TAM) immunosuppression, contributing to ICI resistance in PC.[44] NHC‐diphosphate (triammonium), as a nucleotide analog, could potentially reprogram the TME to affect the ICI response. The gene discussed is P2RY6; the disease is neoplasm.