Recent single‐arm clinical research reported that hearing and speech perception improved significantly in children with autosomal recessive deafness 9 with AAV1‐hOTOF administration.[16, 17] However, there has been no great breakthrough in deafness caused by GJB2 mutation, which is the most commonly mutated gene and accounts for up to 50% of hereditary HL. The gene discussed is GJB2; the disease is deafness.