Because D2HGDH is strongly linked to epilepsy,[16] we used human brain tissue from patients with temporal lobe epilepsy (TLE) (see Table S1, Supporting Information, for details) and tissue from C57BL/6J mice to investigate the precise localization and expression patterns of this gene (Figure1A,B). The gene discussed is D2HGDH; the disease is temporal lobe epilepsy.