D2HGDH and epilepsy: Research has demonstrated that mutations in the D2HGDH gene are responsible for d‐2‐hydroxyglutaric aciduria.[11, 40] If these enzymatic assays capture a relevant cellular event, then the NADP/NADPH ratio and, consequently, the abundance of ROS may also be influenced by D2HGDH expression and mutational status.[10b] This suggests that D2HGDH may be involved in the pathophysiology of epilepsy.[15] However, previous studies have primarily focused on the metabolite, D2‐HG,[10b] overlooking its role in the nervous system.