GPX4 and depressive disorder: 2021). As nicorandil has well‐documented antioxidant property, we hypothesized that it may mitigate depression after TBI by attenuating hippocampal ferroptosis. A key mechanism in preventing ferroptosis involves the SLC7A11/glutathione peroxidase 4 (GPX4) (Chen, Li, et al. 2021), which enhances cystine uptake and promotes glutathione (GSH) synthesis, enabling GPX4 to inhibit lipid peroxidation and inhibit ferroptosis (Chen, Yu, et al. 2021).