MAPT and Mental deterioration: The buildup of hyperphosphorylated p‐Tau into NFTs is a key AD characteristic.[209] Unlike normal tau, p‐Tau cannot effectively stabilize microtubules.[117] Phosphorylated p‐Tau linked with exosomes is found in the CSF of early AD patients, and its CSF levels align with cognitive decline.[210] Notably, higher concentrations of abnormal p‐Tau in exosomes were seen in CSF from AD patients at advanced stages compared to early stages.[33] The release of exosomes increases with neuronal activity.