A study focused on four synaptic proteins – growth associated protein 43 (GAP43), neurogranin, synaptosome associated protein 25 (SNAP25), and synaptotagmin 1‐ which have been implicated in AD pathology.[164] The levels of these proteins in exosomes were significantly lower in the AD group compared to controls, and higher in the aMCI group compared to the AD group.[164] Another study identified a panel of six proteins (A0A0G2JRQ6, C1QC, CO9, GP1BB, RSU1, and ADA10) in circulating plasma exosomes that were associated with AD.[165]. The gene discussed is NRGN; the disease is Alzheimer disease.