ACHE and Parkinson disease: Consequently, neuron‐derived exosomes might be suitable for early PD detection, and oligodendrocyte‐derived exosomes might track PD progression.[169] Additionally, blood‐based exosomal acetylcholinesterase (AChE) activity, which was found to decrease in PD patients compared to healthy individuals, could serve as a reliable early PD diagnostic and prognostic marker.[170]