PROS1 and hyperinsulinemic hypoglycemia, familial, 4: Hypercoagulability can be caused by a variety of factors, including disseminated malignancy, sepsis, puerperium, anti-phospholipid syndrome, Behçet’s disease, systemic lupus erythematosus, oral contraceptive pills, and intrinsic hypercoagulable states, such as antithrombin III deficiency, protein S deficiency, protein C deficiency, prothrombin G20210A mutation, and factor V Leiden mutation [2–5].