CXCR2 and Cowden disease: The expression patterns of these chemokines were consistent with previous findings in experimental colitis models and CD patients.[43, 44] These chemokines play pivotal roles in the infiltration of neutrophils and monocytes, thereby contributing to tissue damage.[45, 46, 47, 48] Our current research identifies a novel role for CCR2 and CXCR2 ligands in the recruitment of MDSCs during intestinal fibrosis.