XIAP and neoplasm: In particular, high XIAP expression is predictive of a poor prognosis in node negative and highly T-cell infiltrated OAC tumors as well as identifying a subset of responders to neo-adjuvant therapy who are prone to relapse35 Whilst XIAP is well established as an anti-apoptotic factor enabling cancer cells to resist cytotoxic therapy, recent evidence has identified XIAP as an important component of tumor-associated inflammation36–38.