This pathway includes components of the acute phase response such as IL1A, IL1B and IL-6 and encompassed multiple genes present in other enriched pathways such as ‘interleukin 10 signaling’, ‘airway pathology in COPD’, ‘roles of cytokines in mediating communication between immune cells’, cell movement related pathways ‘granulocyte/agranulocyte adhesion and diapedesis’. The gene discussed is IL1A; the disease is chronic obstructive pulmonary disease.