We found a higher proportion of CD107a-positive CM CD8 + T cells responding to peptide stimulation than effector memory (EM) T cells, which is consistent with a recent study that evaluated Leishmania braziliensis epitopes in central and effector memory CD4 + and CD8 + T cells from individuals with cutaneous leishmaniasis and healthy controls. This evidence concerns the gene CD4 and cutaneous leishmaniasis.