We discovered that FAT1—at least in part through its intracellular C-terminal domain—is involved in the DDR and represses CIN through the modulation of YAP1, whereas its interaction with YAP1 is dependent on the interaction between FAT1 and the E3 ligase MIB2 (ref. 53). Here, FAT1 is linked to cervical squamous intraepithelial neoplasia.