FAT1 and non-small cell lung carcinoma: Considering the frequency of FAT1 alterations in NSCLC (Figs. 1g and 2, Extended Data Fig. 3 and Supplementary Fig. 5) and its potential role in genome maintenance (Fig. 1d–f), we further elucidated at which stage FAT1 acts in the DSB repair pathway by systematically investigating which mediators were affected by FAT1 depletion 1 h post-ionizing radiation.