To assess how these genes contribute to genome integrity, we performed a multi-parametric RNA interference (RNAi) screen using high-content imaging in four different lung cancer cell lines harbouring mutations in KRAS, EGFR and TP53 to reflect the mutational landscape of the TRACERx cohort (Fig. 1b (top) and Extended Data Fig. 1a). The gene discussed is TP53; the disease is lung cancer.