Most FECD-associated genes so far identified appear linked to late-onset disease26, for example, TCF4 coding for the helix-loop-helix transcription factor E2-237–40, LOXHD141 and SLC4A1142, both coding for plasma membrane proteins and the transcription factor coding gene, TCF8/ZEB116,43,44. The gene discussed is ZEB1; the disease is Fuchs endothelial corneal dystrophy.