Notably, these results were further corroborated by cBioPortal data, which showed that AML patients (n = 25) with high mRNA expression of the genes upregulated by EVAML in our cohort (namely, CAB39, ADA, SLC2A14, CHMP2A, NAT8L, GPX4, CTCF, TPX2, NDUFS8, STAT3, FANCD2 and BRCA1) had decreased OS compared to unaltered AML patients (n = 148) (log-rank, p < 0.04) (Supplementary Fig. 8d, e). Here, CTCF is linked to acute myeloid leukemia.