IL2RG and neoplasm: To define the importance of the immune system in mediating antitumor responses of cytokine-armed pyroptosis, we induced B16F10 tumor formation in immunocompromised B-NDG mice (mice with NOD scid background with IL-2-cytokine family dysfunctionality due to the deletion of the gene coding for the common gamma receptor chain (Il2rg)) that lack functional B, T and NK cells.