Although IFNγ mounts great antitumor response when its production is triggered indirectly (e.g., via IL-12 or IL-18), the overexpression of IFNγ by cancer cells before cell death induction resulted in an abolished antitumor effect (Fig. 7b–d and Supplementary Fig. 11a) corroborating with the RNA sequencing results and in agreement with the reports suggesting IFNγ signaling-mediated suppression of antitumor responses67,68. Here, IL18 is linked to cancer.