GSDMD and neoplasm: However, we further demonstrated that deconstruction of inflammasome with cytokine followed by GSDMD-mediated pyroptosis potentiated antitumor treatment led to 40% long-term tumor-free survival observed for IL-1β and 37.5% for IL-18 (Fig. 4c, d and Supplementary Fig. 6a) compared to electroporation of an empty vector that did not affect tumor regression (Fig. 4c, d).