Interestingly, our sequencing analysis of MpBC cells lacking NOS2 revealed a significant decrease in the expression of pro-inflammatory genes (CXCL8, IL1A, IL1B, IL1RL1), suggesting that there may be crosstalk between tumor-intrinsic iNOS and TME-derived inflammatory cells that may influence tumor EMT programming. The gene discussed is IL1RL1; the disease is neoplasm.