NOS2 and cancer: To fully define the relevance of targeting iNOS in MpBC, we analyzed available transcriptomic data from The Cancer Genome Atlas (TCGA) cBioPortal Combined Dataset (n = 179,290) (cbioportal.org), which showed that ‘MpBC’ was the top breast cancer subtype and 4th highest cancer to harbor NOS2 genomic aberrations (Fig. 1F).