L-NMMA+alpelisib therapy resulted in a significant inhibition of tumor growth relative to single-agent alpelisib therapy in PIK3CA-mutant MpBC PDX models (BCM-3807 [p = 0.0456], PIM-010 [p = 0.0079], and PIM-084 [p = 0.016]) (Fig. 4B–D). This evidence concerns the gene PIK3CA and neoplasm.