demonstrated that ALDH2 could upregulate Beclin‐1 expression, enhance autophagy, and reduce apoptosis in murine models and human renal tubular epithelial cells exposed to Iohexol.[14] Previously, we showed that ALDH2 suppressed glycolysis and lactate production, mitigating mitochondrial dysfunction by interacting with PGC‐1α (a key regulator of mitochondrial biogenesis) in AKI.[15] However, the effects of ALDH2 lactylation and underlying role in regulating mitochondrial function in AKI have not yet been elucidated. The gene discussed is PPARGC1A; the disease is acute kidney injury.