Herein, we established a SiH‐based nanosponge (denoted as SiH/ABR@PLGA) for in situ sustainable hydrogen release, and further cooperated with an alarmin protein S100A8/A9 inhibitor, ABR2575 (ABR) for synergistic anti‐inflammation therapy toward sepsis‐induced ALI (Figure 1). The gene discussed is S100A8; the disease is acute respiratory distress syndrome.