Although we provide evidence that mechanical force‐induced cGAS activation in carcinoma cell facilitates VHPV liver metastasis by recruitment of splenocyte into liver metastatic niche, and both intervening cGAS‐STING‐CCL2 pathway activation and blocking splenocyte migration into liver metastatic niche ameliorate liver metastasis, further investigation into the cell type of splenocyte and exploration of useful cGAS inhibitor are warranted. Here, CGAS is linked to carcinoma.