Previously, the spleen has been proven to serve as a monocyte reservoir to accommodate the demands of rapid‐onset inflammation in conditions.[40, 44] Manipulating cGAS‐STING activation and expression to attenuate splenic monocytes/macrophages infiltration in liver not only occurs at the onset of cancer cell colonization, but also inhibits CD11b+ and F4/80+ myeloid cell infiltration in metastatic solid tumors. Here, CGAS is linked to cancer.