It has been reported that Hspa13 restricts viral infection by modulating the type I interferon antiviral pathway and the NLRP3 inflammasome, revealing the antiviral effects of Hspa13.[25] In one of our previous studies, Hspa13 was proved to be critical for plasma cell development.[26] In this study, the findings reported the novel functions of Hspa13 in regulating IL‐10 production and the immune regulatory function of B cells by supporting Tregs differentiation. This evidence concerns the gene NLRP3 and viral infectious disease.