IL10 and systemic lupus erythematosus: The classical roles of HSPs are they function as intracellular chaperones in maintaining proteostasis.[17] Notably, HSPs can act as immunogenic proteins and are involved in the pathogenesis of autoimmune diseases, including SLE.[18, 19, 20] The immunomodulatory effects of HSPs, which regulate cytokine production or induction of IL‐10 producing T cells or CD4+Foxp3+Tregs, have been explored in autoimmune and some immune disorders.[21] However, the immunoregulatory function of HSPs in B cells remains unclear.