For example, some studies have found increased circulating Breg numbers and serum IL‐10 levels in patients with SLE.[14, 15] While, other studies have also described decreased numbers or impaired functions of Breg subsets in patients with SLE.[13, 16] Thus, further elucidation on the critical factors regulating IL‐10 production and functional features of Bregs are still necessary to understand SLE pathogenesis. The gene discussed is IL10; the disease is systemic lupus erythematosus.