METTL3 and infection: In addition, studies performed in germ‐free mouse models showed that m6A modification in the intestine can be regulated by the microbiome.[17, 18] Infection of tumor cells with Fusobacterium nucleatum increases METTL3 transcription, thereby affecting the level of m6A modification.[48] However, research on how microbes affect m6A modification in the host intestine is still limited.