SEMA4A and skin disorder: When psoriasis-like dermatitis was induced in wild-type (WT) mice and Sema4A knockout (KO) mice by imiquimod (IMQ) application on ears (Figure 2A), ear swelling on day 4 was more pronounced in Sema4A KO mice (Figure 2B) with upregulated Il17a gene expression (Figure 2C).