SEMA4A and experimental autoimmune encephalomyelitis: While Sema4A expression on T cells is essential for T helper type 1 differentiation in the murine Propionibacterium acnes-induced inflammation model and delayed-type hypersensitivity model (Kumanogoh et al., 2005), Sema4A amplifies only T helper type 17 (Th17)-mediated inflammation in the effector phase of murine experimental autoimmune encephalomyelitis (Koda et al., 2020).