Semaphorin 4A (Sema4A), one of the immune semaphorins, plays both pathogenic and therapeutic roles in autoimmune diseases (Cavalcanti et al., 2020; He et al., 2023), allergic diseases (Maeda et al., 2019), and cancer (Iyer and Chapoval, 2018; Liu et al., 2018; Naito et al., 2023a; Pan et al., 2016). The gene discussed is SEMA4A; the disease is cancer.