IL17A and psoriasis: While the infiltration of immune cells into skin plays a critical role in the development of psoriasis, as evidenced by interleukin (IL)-23/IL-17 axis (Fitch et al., 2007; Hawkes et al., 2018; Kim and Krueger, 2017), recent studies have revealed that cells constructing skin structure, such as keratinocytes, fibroblasts, and endothelial cells, also play pivotal roles in the development (Heidenreich et al., 2009; Lowes et al., 2013; Zhang et al., 2023) and maintenance (Arasa et al., 2019; Francis et al., 2024; Li et al., 2023; Ma et al., 2023; Tan et al., 2015; Zhu et al., 2020) of psoriasis.