In this study, we used FLU to inhibit M1 polarization by inhibiting STAT‐1 phosphorylation, and we used IL‐4 to promote M2 polarization by promoting STAT‐6 phosphorylation; we found that inhibiting M1 polarization or promoting M2 polarization could significantly attenuate IBD symptoms. Here, STAT1 is linked to inflammatory bowel disease.