Like other NR4A orphan nuclear receptors, NR4A1 is a mediator of cyclic adenosine monophosphate response element binding protein (CREB)‐dependent neuroprotection and has been proposed as a potential therapeutic target for AD, as its ortholog's pharmacological activation in mice was shown to rescue age‐associated memory decline.53 This evidence concerns the gene NR4A1 and Alzheimer disease.