Given the established association between Aβ accumulation and increased signal transducer and activator of transcription 3 (STAT3) phosphorylation in AD,58 a particularly noteworthy finding is the enrichment of genes involved in the positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531, adjusted P value = 0.05). The gene discussed is SOAT1; the disease is Alzheimer disease.