Among T cells, the overall pattern of depletion of naïve subsets and enrichment of differentiated subsets characteristic of DS (Waugh et al., 2019; Araya et al., 2019; Malle et al., 2023; Galbraith et al., 2023) is conserved across subgroups, as illustrated by consistent depletion of CD8+ naive subsets along with increases in the CD8+ terminally differentiated effector memory (TEMRA) subset (Figure 2f, Figure 2—figure supplement 1d). This evidence concerns the gene CD8A and Dravet syndrome.