IL17C and Dravet syndrome: We then compared the effects of age versus T21 status on cytokine levels in the DS cohort, which identified many inflammatory factors elevated in DS across the lifespan that do not display a significant increase with age, such as IL-9 and IL-17C, or that increase with age only in the DS cohort, such as IP-10 (Figure 3e–f, Figure 3—figure supplement 1e).