IFNA1 and Dravet syndrome: The fact that gene signatures of IFN hyperactivity are present in human embryonic tissues with T21 (Bhattacharya et al., 2023) and embryonic tissues from mouse models of DS (Aziz et al., 2018; Waugh et al., 2023) indicates that the harmful effects of IFN hyperactivity could start in utero, supporting the notion that DS could be understood, in part, as an inborn error of immunity with similarities to monogenic interferonopathies (Rodero and Crow, 2016).