IFNA1 and psoriatic arthritis: Furthermore, we recently demonstrated that IFN transcriptional scores derived from peripheral immune cells correlate significantly with the degree of immune remodeling and hypercytokinemia in DS (Galbraith et al., 2023), and we and others have reported the safe use of JAK inhibitors for treatment of diverse immune conditions in DS, including alopecia areata (Rachubinski et al., 2019), psoriatic arthritis (Pham et al., 2021) and hemophagocytic lymphohistocytosis (Guild et al., 2022) through small case series.