IFNAR2 and Dravet syndrome: In mouse models, triplication of four IFNR genes contributes to multiple hallmarks of DS (Maroun et al., 2000; Waugh et al., 2023) and JAK inhibition attenuates global dysregulation of gene expression (Galbraith et al., 2023) while rescuing key phenotypes, such as lethal immune hypersensitivity (Tuttle et al., 2020) and CHDs (Chi et al., 2023).