It is well established that individuals with DS display elevated levels of many inflammatory markers, including several interleukins, cytokines, and chemokines known to drive autoimmune conditions, such as IL-6 and TNF-α (Sullivan et al., 2017; Zhang et al., 2017; Malle et al., 2023; Galbraith et al., 2023). The gene discussed is TNF; the disease is Dravet syndrome.