Gene ontology enrichment analysis of activated genes upon viral infection revealed strong activation of immune response associated pathways including defense response to virus, regulation of innate immune response, response to interferon‐beta, regulation of inflammatory response, and tumor necrosis factor production in all the mouse models (Fig. 3C,D), indicating an overall successful infection of SARS‐CoV‐2 on all tested mouse models. This evidence concerns the gene TNF and viral infectious disease.