Additionally, circulating neutrophils with a hyper reactive phenotype have been shown to correlate with the rate of cognitive decline in Alzheimer's disease.23 Interestingly, treatment with kynurenic acid, a neuroprotective metabolite in the kynunerine pathway, in rats with sepsis showed reduced BBB injury, reduced brain mitochondrial dysfunction and reduced NET formation (CitH3 and MPO).49 In the present study, levels of cell-free DNA in serum and CSF were not inter-correlated. The gene discussed is MPO; the disease is early-onset autosomal dominant Alzheimer disease.