For example, Jingli and others have shown that high levels of CRP are positively correlated with the occurrence and progression of CKD, suggesting that chronic inflammation may lead to a decline in renal function by acting on renal tubular cells and glomeruli (46), in addition, inflammatory-mediated apoptosis and fibrotic processes may also play an important role in patients with coexisting COPD and CKD. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.