Among the significant DEGs shown in in Figure 3B, tumor specimens overexpressed genes like MUC5B, encoding for the glycoprotein mucin, AEBP1 (AE binding protein 1), SPARCL1 (SPARC-like protein 1), RBX1 (ring box-1) and ELN (elastin). In contrast, genes such as ALDOA (aldolase A), U2AF1 (U2 small nucleolar RNA auxiliary factor 1), MFSD14A (major facilitator superfamily domain containing 14A) and FKBP2 (FKBP prolyl isomerase 2) were upregulated in patient-derived cell lines. The gene discussed is SPARCL1; the disease is neoplasm.