Interferon-induced protein 44-like (IFI44L) is an identified gene that is involved in various cancerous and non-cancerous diseases including oral cancer (OC), renal cell carcinoma (RCC), Sjogren’s syndrome (SS), and systemic lupus erythematosus (SLE) (1–4). Here, IFI44L is linked to systemic lupus erythematosus.