ADIPOQ and Hepatic fibrosis: This review explored alterations in ADPN levels in liver fibrosis and its regulatory functions, elucidates how ADPN and its receptors reduce endoplasmic reticulum stress (ERS) in hepatocytes, surveys current ADPN detection methods, and evaluates the potential of ADPN as a promising biomarker for early diagnosis of liver fibrosis and as a therapeutic agent for liver fibrosis treatment.