CD44 and neoplasm: We also resolved the communication patterns in the tumor microenvironment by NMF analysis, which also helped us to identify the specificity of myeloid precursor cells in communication (Figures 2H, I).The MIF pathway played multiple roles in the communication process of myeloid precursor cells, through which myeloid cells mainly communicated with monocytes and B-cells, and the cellular expression of MIF, CD74 and CD44 genes MIF, CD74 and CD44 genes were expressed at high levels in the cells and were the main ligand receptors mediating the communication through this pathway (Figures 2J–L).