Direct immune-mediated kidney diseases involve ones such as membranous nephropathy (MN) and anti-glomerular basement membrane(anti-GBM) glomerulonephritis, whereas indirect immune-mediated kidney diseases encompass Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAVs), IgA nephropathy (IgAN), lupus nephritis (LN) (14), as well as diabetic kidney disease (DKD) and angiotensin II-induced kidney injury (15, 16). This evidence concerns the gene AGT and diabetic kidney disease.