In patients with psoriasis, neutrophils are pre-activated and form a NET in psoriatic skin lesions (155, 156) NET promote keratinocyte to secrete high levels of proinflammatory factors (LCN2, IL-36γ, CXCL8, and CXCL1) by activating TLR4/IL-36R crossers and the downstream MyD88/NF-κB signaling pathway (156). This evidence concerns the gene CXCL8 and psoriasis.