SerpinB3 expression is elevated in the skin lesions of GPP patients with SerpinB3 mutation (72). SerpinB3-derived protein Pso p27, an autoantigen in psoriasis, increases inflammation and promotes migration of immune cells. The increase in expression of SerpinB3 in the skin can promote inflammation and poor differentiation of keratinocyte (73–77). The gene discussed is SERPINB3; the disease is psoriasis.