Specifically, NF-κB enhances endothelial cell dysfunction and inflammation (35), increases pro-inflammatory cytokines, and promotes the infiltration of lymphocytes and macrophages from the vascular lumen into the subendothelial layer of the arterial intima (35, 91, 93), thereby contributing to the development of aortic aneurysms. Here, NFKB1 is linked to aortic aneurysm.