CRP and triple-A syndrome: Among 803 downregulated genes, MRTFA (myocardin-related transcription factor A), which is involved in the survival and proliferation of pro-atherogenic macrophages (20) and plays a protective role in the vascular wall by mitigating vascular degeneration (21), was significantly downregulated in CD68-positive macrophage in AAA–high-CRP group (Figure 3C).