CALCA (calcitonin gene–related peptide alpha) is a potent microvascular vasodilator (65), is considered a therapeutic target for subarachnoid hemorrhage-triggered cerebral vasospasm and is known to play a protective role in vascular diseases such as hypertension (66); however, its direct role in aortic aneurysms remains to be elucidated. This evidence concerns the gene CALCA and Hypertension.