CXCL8 promotes M2 polarization (22); PTGER1 (prostaglandin E2 receptor 1) fine-tunes the inflammatory response and M1-M2 macrophage polarization; CNR2 [cannabinoid receptor 2 (23, 24)] facilitates the polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype and inhibits the NF-κB pathway to mitigate inflammation; GPR32 (G protein–coupled receptor 32) resolves inflammation and reduces atherosclerosis (25, 26); and IL-36B (interleukin-36 beta) promotes phagocytosis and clearance in macrophages (27). The gene discussed is PTGER1; the disease is atherosclerosis.