PDGFRB and gastrointestinal stromal tumor: PDGF, a fundamental protein stored in platelet α-granules (41), along with its receptors (PDGFRα and PDGFRβ), is expressed in numerous malignant cells and tissues, including NSCLC, gastrointestinal stromal tumors (GIST), and pancreatic, breast, ovarian, hepatocellular, and neuroendocrine cancers (42).