The latest study has shown that AKR1B10 was positive in only 12.16% of the tumor tissues of 592 patients with CRC, while AKR1B10 was not detected in 63.13% of tumor tissues, so it is speculated that AKR1B10 may be an oncogenic factor rather than a prognostic indicator for CRC (58). This evidence concerns the gene AKR1B10 and colorectal carcinoma.