AKR1B10 knockdown results in decreased levels of PI3K and AKT phosphorylation, suggesting that AKR1B10 promotes proliferation, migration, and invasion of HCC cell through the PI3K/AKT signaling pathway, and this pathway has an important reference value for the assessment of HCC (39–43). Here, AKR1B10 is linked to hepatocellular carcinoma.