The researchers used the DepMap dataset to analyze AKR1B10 by gene effector CRISPR (DepMap Public 22Q4 + Score, Chronos) and found that upregulation of AKR1B10 expression is associated with poorer overall survival, and that HCC cell proliferation, migration, and invasion are influenced by AKR1B10 activity (39). This evidence concerns the gene AKR1B10 and hepatocellular carcinoma.