Nrf2 agonists, such as dimethyl fumarate and signal transducer and activator of transcription 3 (STAT3), mitigate ferroptosis in intestinal IRI-ALI by increasing the mRNA expression of FTH1 and GPX4, reducing lipid peroxidation, and preserving GSH levels through upregulation of SLC7A11. Here, STAT3 is linked to acute respiratory distress syndrome.