Therefore, investigation the prognostic value of markers in the NETs/AIM2 inflammasome axis, such as MPO-DNA, PAD4, HMGB1, C1q, AIM2, ASC, Caspase-1, IL-1β, IL-6 and IL-8, in LAA stroke patients is a meaningful endeavor. The gene discussed is CASP1; the disease is Stroke.