A report found that SGK1 mRNA and protein are upregulated after seizures (Wang et al., 2010), specifically they explored the relationship between SGK1 expression and epileptogenesis by measuring SGK1 expression in human brain tissues and experimental models of epilepsy in rats, and found that the expression of SGK1 was enhanced in the temporal lobe neocortex of epileptic patients at different stages of the epileptic process. This evidence concerns the gene SGK1 and epilepsy.