NEDD4L and epilepsy: Based on the above results, a transgenic mouse model of epilepsy induced by Carthocyanine (KA) further revealed that Nedd4–2 is a substrate for SGK1.1 in hippocampal neurons and constitutes a regulatory pathway by which SGK1.1 regulates M current in the hippocampus (Armas-Capote et al., 2020).