Meanwhile, some studies have shown that sleep deprivation increases the production of Aβ in the brain (Slats et al., 2013), and by overlapping differentially expressed genes between sleep deprived mice and AD mice, the Sgk1 gene was found to be deregulated in both sleep deprived mice and AD mice, which implies a possible role of SGK1 in the treatment of AD(Wei, 2020). This evidence concerns the gene SGK1 and Alzheimer disease.