MAPT and Alzheimer disease: Alzheimer's disease (AD) is the most common type of dementia and is defined as a slowly progressive neurodegenerative disease characterized by neuroinflammatory plaques and neurofibril tangles (nfts), which are the result of accumulation of β-amyloid (Aβ) and hyperphosphorylation of tau proteins consisting of nfts in the brain's medial temporal lobes and neocortical structures (De-Paula et al., 2012).